Announcing STCA Funded TCC Screening Study at Purdue University
IMPORTANT NEWS RELEASE!!
In advance of the publication of the STCA’s Bagpiper #3, the HTF is excited to announce that the STCA has approved HTF funding of a brand new TCC Screening Study at Purdue University!
The title of the new study is Screening and Early Intervention to Positively Transform the Management of Urinary Bladder Cancer in Scottish Terriers
Dr. Debbie Knapp plans to follow a population of 100 or more Scotties over a 3-year period with twice-a-year screenings. The ultimate goal of this study is the development of a successful and routine screening protocol for Scotties and other high-risk breeds, leading to early intervention when needed, using a relatively low risk medication. This protocol may save the lives of thousands of dogs, reduce the side effects from traditional cancer treatment, and will help to lower health care costs for the owners.
The study is now officially funded and paperwork is signed. Screenings will begin after September 1, 2014.
Who is eligible? Any Scottie 7 years of age or older, with no evidence of urinary tract disease, in good health, with no diagnosis of any cancer or major organ dysfunction. Must be able to travel to one of 3 locations in the Midwest US.
The screenings every 6 months will consist of: 1) physical exam; 2) urinary tract ultrasound; 3) urine collection by free catch for urinalysis and many other urine tests; 4) blood collection for routine chemistry and other tests; and, 5) Informed consent paperwork to be signed by the owners.
There will be no charge to the owners for these procedures.
If any abnormalities are discovered on ultrasound, further diagnostic work up will be offered at Purdue, again at no charge. If there is a diagnosis of TCC from biopsy taken by cystoscopy, then the Scottie will be eligible to be placed on a daily pill called Deramaxx, which is a drug similar to piroxicam. There will be no charge for the Deramaxx.
Screenings will be held year round at Purdue in West Lafayette IN.
In addition, two other off campus locations will hold 1-2 day screening clinics in the Spring and Fall. These 2 locations are Capitol Illini Veterinary Clinic, Chatham, IL and Metropolitan Veterinary Specialty Services, Louisville, KY.
Watch for the full article with much more detail to appear in the STCA's Bagpiper #3 in September.
For questions or to enroll Scotties in the study, contact: Christine K Royce
For more information on local clinic sites, please contact Rose Shacklett, Coordinator for the Louisville, KY clinic or Lisa Hills, coordinator for the Springfield clinic.
Funding for Canine Cerebellar Abiotrophy
Sponsorships for Canine Cerebellar Abiotrophy (CA) Scottish Terrier Club of America
Below is a pdf containing the funding for Cerebellar Abiotrphy sponsored by the STCA HTF. The funding is actually two separate grants. The funding was matched by the AKC. This is part of the funded projects sponsored by the HTF.
Study Location: Ostrander Laboratory at the National Human Genome Research Institute at NIH, in collaboration with the Purdue Comparative Oncology program at Purdue University
Cancer is a major cause of death in older dogs and treatment is often ineffective. We wish to identify the causes of cancer in order to learn how to more effectively predict, prevent, and treat the disease. Genetic (heritable) factors are important in the development of Transitional cell carcinoma (TCC) of the bladder. The Scottish and West Highland White terriers and the Shetland sheepdog are at high risk for TCC, suggesting that subsets of dogs from each of these breeds are born with errors in critical genes that predispose them to TCC. We wish to develop ways to identify the dogs with genetic risk factors for TCC before they get the disease. Dogs at risk could then either enter cancer prevention trials, undergo screening tests to detect cancer at its earliest state, and, in the future, possibly receive “genetic” therapy. We have found two regions of the genome where error-prone genes lie and have narrowed the first region to a few hundred bases in an interval that has only two genes. We are requesting continued support to allow us to find this mutation as well as fine map the remaining critical gene(s). To do this we need blood samples from dogs that have been diagnosed with TCC of the bladder as well as healthy dogs over the age of 10 that have never had any form of cancer.
List of research projects funded through the AKC Canine Health Foundation in recent years. Many of the projects are underway at this time, though some of the projects have been completed.
HTF Statement of Limitations on Financial Support for Research Projects*
The HTF does not financially support the following:
Salary of tenure-track faculty (university) or professional, salaried senior-staff (non-profit or for-profit)
Salary of tenure-track faculty (university) or professional, salaried senior-staff (non-profit or for-profit) for statistical analysis support
Laboratory equipment or non-disposable parts
Laboratory equipment repair or non-disposable parts
Development of custom-designed computer software
Tuition or registration fees for classes, training, or conferences
Travel expenses for any purpose, except those directly related to sample procurement (example: dog shows, scheduled clinics)
Transportation of dogs
The HTF will pay up to a maximum of 8% Indirect Costs.
*In Accordance with the AKC CHF Grant Application
Grant 01827 (2013) High-throughput (metagenomic) sequencing for identification of bacteria associated with canine periodontitis and oral health. Marcello Pasquale Riggio; University of Glasgow Project Dates: 1/1/2013 to 1/31/2014 Sponsorship Payment: $1,200
Grant 01602 (2012) Longitudinal Study Investigating the Progression and Pathogenesis of Atypical Hyperadrenocorticism in Scottish Terriers Kurt Zimmerman; Virginia-Maryland Regional College of Veterinary Medicine Project Dates: 1/1/2012 to 12/31/2013 Sponsorship Payment: $10,000
Grant 01577 (2012) Fine Mapping of Loci for Transitional Cell Carcinoma in the Scottish Terrier, West Highland White Terrier, and Shetland Sheepdog Elaine A Ostrander; National Human Genome Research Institute Project Dates: 1/1/2012 to 12/31/2013 Sponsorship Payment: $5,000
Grant 01592 (2012) Investigation into the Genetics of Scottie Cramp: Sequencing of Associated Chromosomal Regions Natasha J Olby; North Carolina State University Project Dates: 1/1/2012 to 6/30/2013 Sponsorship payment: $10,000
Grant 01413 (2011) Investigation into the Genetics of Scottie Cramp: a Genome-Wide Association Study Natasha J Olby; North Carolina State University Project Dates: 1/1/2011 to 3/31/2012 Sponsorship Payment: $23,250
Grants 1336-A&B (2010) Finding the Mutations that Increase Susceptibility to transitional Cell Carcinoma in the Scottish Terrier, West Highland White Terrier, and the Shetland Sheepdog Dr. Deborah Knapp, DVM; Dr. Elaine Ostrander, PhD Purdue University: National Human Genome Research Institute Project Dates: 1/1/2010 to 12/31/2011 Sponsorship Payment: $10,000
Grant 1384-A(2010)Improved Imaging to Monitor Therapy Response of Urinary Bladder Cancer Using 3D Volume Ultrasonography Dr. James F. McNaughton, DVM Purdue University Project Dates: 2/1/2010 to 7/31/2011 Sponsorship Payment: $1,000
Grant 1131 (2009) Genetic Background and the Angiogenic Phenotype in Cancer Dr. Jaime Modiano, VWD, PhD University of Pennsylvania
Grant 1105 (2009) Understanding the Dynamics of Canine Influenza Virus Transmission In Dog Populations and Intervention Strategies for Reducing Transmission Dr. Cynda Crawford, DVM, PhD University of Florida
Grant 896 (2007) Clinical Trial and Pharmacokinetics of Intravesical Mitomycin C(MMC) for Treatment of TCC Dr. Deborah Knapp. Purdue University
Purdue Bladder Cancer Study
Purdue University recently completed a health study that was jointly funded by the STCA Health Trust Fund and the AKC Health Foundation. This material was just published in the April 15, 2004 issue of the Journal of the American Veterinary Medicial Association. It is titled "Herbicide exposure and the risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers". The STCA HTF is pleased to announce that a summary of this study (in briefing format) is available on the STCA web site. (Click here)
The Purdue researchers are planning to publish several more articles based on this research. Dr. Glickman, one of the researchers, is especially excited about one of the articles which will describe the relationship in Scotties between consumption of fresh vegetables on a regular basis and a reduced risk of cancer. This relationship should not be surprising based on what has been found from studies in humans. However, finding the same thing in dogs hopefully will send a message to pet food companies that maybe their current foods are not optimal and could be modified for the better.